HYPERHIDROSIS SCIENCE: Hyperhydrosis research, treatments - excessive sweating knowledge


HYPERHIDROSIS KNOWLEDGE AND SCIENCE


JUNE 2006: Sweating associated with diseases no-sweat-line



Medical Publication:

Hyperhidrosis: a new and often early symptom in Fabry disease.

International Journal of Clinical Practice. 60(9): 1053-9, 2006. no-sweat-line


Synopsis: Fabry disease is an inherited disorder that affects the heart, kidneys and nerves, and often times leads to an increase in sweating and even hyperhidrosis.


Fabry disease results from an enzyme deficiency that leads to the deposit of fatty substances in the blood vessels. One of the hallmark symptoms of Fabry disease is hypohidrosis, that is, an increase in sweating. These authors described the unusual cases of Fabry disease patients with hyperhidrosis, i.e. excessive sweating. They found that females more often had hyperhidrosis than males, and the onset of the excessive sweating appears in childhood or adolescence. The authors do not postulate why some people with Fabry disease exhibit excessive sweating, while most people with the disease exhibit decreased sweating.


Conclusion: The authors present several patients with hyperhidrosis who suffer from a genetic disorder that usually presents itself with decreased sweating. Their parting comment is very telling. Basically, concerning hyperhidrosis future research, the efficacy of enzyme replacement therapy should be assessed. Replacing the missing enzyme in Fabry disease, which is easier said than done, should yield some interesting data regarding the treatment and causes of sweating disorders, such as excessive sweating or hyperhidrosis.




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