HYPERHIDROSIS SCIENCE: Hyperhydrosis research, treatments - excessive sweating general knowledge


HYPERHIDROSIS KNOWLEDGE AND THE SCIENCE OF HYPERHYDROSIS


We take hyperhidrosis seriously. We feel that everyone should have access to as much knowledge and information on hyperhydrosis (HH) and related excessive sweating issues as possible, so that they can make the healthy, informed choices regarding their sweating condition and/or problems. We will be updating this hyperhidrosis page regularly in order for you to have the most up-to-date scientific knowledge on excessive sweating. The following are just samples; please click on the hyperhidrosis article titles, "read more..." or the links to the left to read the full articles.



August 2007: Risk with Exertion for Thoracic Sympathectomy for Hyperhidrosis no-sweat-line

Medical Publication:

Is Previous Throacic Sympathectomy a Risk Factor for Exertion?

Annals of Thoracic Surgery, 84(3): 1025-7, 2007.

no-sweat-line

Synopsis: A review of experiments involving the depth of cuts during surgery for hyperhidrosis.


The hyperhidrosis scenario: A physically fit and healthy young man had a heat stroke after running a 10 kilometer race. He had previously received a bilateral thoracic sympathectomy for excessive sweating and was known to have reduced upper body sweating.


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July 2007: Experiments with Cutting Nerves at Different Levels for Hyperhidrosis no-sweat-line

Medical Publication:

Treatment of palmar hyperhidrosis: T(4) level compared with T(2) and T(3).

Annals of Surgery, 246(2):: 330-6, 2007.

no-sweat-line

Synopsis: A review of experiments involving the depth of cuts during surgery for hyperhidrosis.


The authors compared a surgical procedure which cuts the nerves at the so-called T(4) level, with cuts at other levels in the spinal chain as a treatment for excessive sweating. They found that the T(4) procedure was better and more effective for treatment of hyperhidrosis compared to the other two.


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June 2007: Persistant Blisters After ETS for Hyperhidrosis no-sweat-line

Medical Publication:

Severe pomphylox following endoscopic thoracic sympathectomy for hyperhidrosis.

Interactions in Cardiovascular Surgery, 3(4):593-5, 2007

no-sweat-line

Synopsis: Ongoing blisters in two patients who had ETS for their hyperhidrosis.


A case report of two persons who unfortunately developed persistent small blisters on the palms as a result of their surgery to cure excessive sweating of the palms. One person's condition resolved with creams, the other one's did not.


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May 2007: Liposuction-Curettage Treatment of Axillary Hyperhidrosis no-sweat-line

Medical Publication:

Repeat liposuction-curettage treatment of axillary hyperhidrosis effectiveness

Acta Neurol Taiwan 16(1):64-5, 2007

no-sweat-line

Synopsis: Patients with repeat liposuction-curettage for treatment of their hyperhidrosis of the underarms have a decent success rate, however questions linger...


Patients who previously had undergone liposuction-curettage for treatment of excessive sweating of the underarms, and who were not satisfied with their results, underwent a repeat procedure. The authors relate that 84% of those who underwent the repeat procedure were satisfied with their results in reducing underarm hyperhidrosis to an acceptable level.


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April 2007: Hyperhidrosis After Stroke Case Study no-sweat-line

Medical Publication:

Contralateral Hyperhidrosis After Intracerebral Hemmorage

Acta Neurol Taiwan 16(1):64-5, 2007

no-sweat-line

Synopsis: Single case study on an occurrence of hyperhidrosis after a stroke.


A case report of a person who had a stroke and developed excessive sweating on the opposite side of the body from where the stroke affected the brain, which of course makes sense due to the fact that right side of the brain controls the left side of the body and vice versa. Therefore, it would makes sense that the hyperhidrosis also developed on the other side of the body, opposite of the stroke area.


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March 2007: Recommendations for Facial Hyperhidrosis no-sweat-line

Medical Publication:

Facial hyperhidrosis: Best Practice Recommendations and Special Considerations.

Cutis 79:29-32, 2007

no-sweat-line

Synopsis: Authors review facial hyperhidrosis remedies with special considerations.


The authors review treatment methods for excessive sweating on the face. Foremost, they acknowledge that facial hyperhidrosis may be secondary to other causes, such as thyroid problems, tumors, etc. Aside from using topical antiperspirants to treat facial hyperhidrosis, the authors cite the use of Botox injections. They caution that, although Botox can be effective for excessive sweating of the face, it is not without side effects. These can include facial assymetry and/or drooping eyelids. Also, use of Botox for facial hyperhidrosis can be expensive, as it is impermanent (which means repeat injection sessions), and is not usually covered by insurance.


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February 2007: Surgery for Palmar Hyperhidrosis no-sweat-line

Medical Publication:

Outpatient Microthoraacosopic Sympathectomy for Palmar Hyperhidrosis

Miller, D.L. and Force, S.D. Annals of Thoracic Surgery, 83(5): 1850-3, 2007

no-sweat-line

The authors report a 99% success rate in sympathectomy surgery for excessive sweating. 12% of patients developed the complication of compensatory hyperhidrosis.


This was a study of 50 patients with excessive sweating who opted for surgery to correct their hyperhidrosis problems. There were 41 women and 9 men in the study. Thoracic sympathectomy was performed in all patients.


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January 2007: Oral Treatments for Hyperhidrosis no-sweat-line

Medical Publication:

Use of Oral Glycopyrronium Bromide in Hyperhidrosis

Bajaj, V. and Langtry, J.A. British Journal of Dermatology: 2007

no-sweat-line

Synopsis: Good results were obtained with oral glycopyrronium bromide in treating people with excessive sweating. However, at least a third of the people being treated had quite a few side effects.


Glycopyrronium bromide is an anticholinergic drug that can be used orally to treat hyperhidrosis. In a series of 24 patients, nine with generalized hyperhidrosis and 15 with localized hyperhidrosis, 79% responded to the treatment with oral glycopyrronium bromide.


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DECEMBER 2006: Oral Drugs for Hyperhidrosis no-sweat-line

Medical Publication:

Oxybutynin for Patients with Hyperhidrosis

Netherlands Journal of Medicine 64(9): 326-8, 2006

no-sweat-line

Synopsis: An oral drug, oxybutynin, helped one woman with her hyperhidrosis.


This is a single case report on the treatment of hyperhidrosis on a woman in the Netherlands. She had a history of excessive sweating of the face (facial hyperhydrosis) and upper body. When her general practitioner prescribed her oxybutynin for urinary incontinence, it had the added side effect of curing her sweating problem, hyperhydrosis. Apparently, the anticholinergic effect of oxybutynin, which was designed to help the urinary problem, also aided the excessive sweating or hyperhidrosis.


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Medical Publication:

Paroxetine useful for palmar-plantar hyperhidrosis

Annals of Pharmacotherapy 40(10): 1884-6, 2006

no-sweat-line

Synopsis: An oral drug, paroxetine, proved useful for a man with hyperhidrosis on the palms and soles.


Once again, this is a single case report of a drug that works for hyperhidrosis. However, as opposed to the case of the woman from the Netherlands, who suffered from sweating on the upper part of her body, this 32 year old man suffered from excessive sweating on his palms and soles (palmar hyperhydrosis and plantar hyperhydrosis). The man had hyperhidrosis of the palms and soles since childhood. He experienced a marked reduction in sweating, and improvement in socio-occupational functioning. More specifically, his sweat reduction, or the waning of his hyperhidrosis, greatly improved his social and work life.


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OCTOBER 2006: Surgical Treatments for Hyperhidrosis no-sweat-line

Medical Publication:

Thoracic Sympathicolysis for Primary Hyperhidrosis:
A Review of 918 Excessive Sweating or Hyperhidrosis Procedures.

Surgical Endoscopy 20j(4): 598-602, 2006 no-sweat-line


Synopsis: 458 patients underwent surgery for treatment of heavy sweating or hyperhidrosis (HH) . The authors report an overall satisfaction rate of 88.5% for people's hyperhydrosis, but also report a high complication rate.


Thoracic sympathicolysis is a mouthful. What this long-winded term means is that it is a surgical procedure for excessive sweating where the sympathetic nerves that cause sweating are cut. This has become an alternative for people who have an extremely disturbing excessive sweating problem of the palms and underarms (palmar hyperhidrosisaxillary and hyperhidrosis) that is uncontrolled by any other means (antiperspirants, botox, etc.).


This group of excessively sweating patients was comprised of 143 men (31%) and 315 women (69%). This is not an outpatient procedure. The average hospital stay was 17 days! 97.4% of heavily sweating patients experienced a total cessation of sweating in the affected areas. There was a 3.6% incidence of major complications including pneumothorax (punctured lung), subcutaneous emphysema (air under the skin), bleeding in the chest and collapsed lung.


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Medical publication:

Improved quality of life after sympathetic block for upper limb hyperhidrosis.

British Journal of Surgery 93(5):582-6, 2006. no-sweat-line


Synopsis: 106 patients underwent endoscopic thoracic sympathetic block (ETS) for treatment of underarm and palmar excessive sweating. Satisfaction rates were almost 100%, but complication rates were also high.


As in the previous study, most patients were happy with the decrease in underarm and palmar sweating. However, the complication rate was disturbing. 17% had compensatory sweating and 28% had gustatory sweating. Notice how the complication rate from this study differs from the complication rate in the previous study. A 28% rate of compensatory gustatory sweating in this study compared to a 1% incidence in the previous study.


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Medical Publication:

Surgical treatment of axillary hyperhidrosis

A study comparing liposuction cannulas with a suction-curettage cannula. Annal of Plastic Surgery 56(6):654-7, 2006. no-sweat-line


Synopsis: These surgeons prefer the suction-curettage technique for excessive underarm sweating.


As we have seen above, there are different techniques available for treatment of axillary hyperhidrosis, a.k.a. underarm sweating. Suction-curettage is a surgical procedure that is less invasive than ETS. It involves the numbing of the underarm area with the insertion of a suction cannula, similar to liposuction, and the scraping of the sweat glands in the underarms. These authors compared the success rates of different suction techniques. Sweating was reduced by 44 percent using the 1-hole liposuction cannula and by 62 percent using the suction-curettage cannula. As opposed to the previous studies, there were no severe side effects.


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AUGUST 2006: Non-Surgical treatments for hyperhidrosis no-sweat-line

Medical Publication:

Mydriasis and accommodative failure from exposure to topical glycopyrrolate used in hyperhydrosis.

Journal of Neuroophthalmology 26(3):232-3, 2006. no-sweat-line


Synopsis: Topically applied glycopyrrolate can help sweating but can cause ocular side effects.


Glycopyrrolate is a drug used to treat ulcers. It acts by blocking the cholinergic system of nerves in the gut thereby decreasing acid secretion. This anticholinergic effect is also helpful in reducing sweating. Previous reports have shown that topical glycopyrrolate can have some effect on reducing excessive sweating.


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Medical publicaton:

Facial hyperhidrosis-induced social fear alleviated with topiramate.

Journal of Clinical Psychiatry, 67(7): 1157, 2006. no-sweat-line


Synopsis: Orally administered toprimate can help to decrease facial sweating.


Well, remember the study before this one(treatment of inguinal hyperhidrosis). All drugs can have negative side effects as well as good effects. Topiramate is a drug used to control seizures. One of the side effects, as in the case of glycopyrrolate, is decreased sweating.


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Medical publication:

Treatment of inguinal hyperhidrosis with botulinum
toxin type-A.

International Journal of Dermatology 45(8): 985-6, 2006. no-sweat-line


Synopsis: Excessive sweating in the groin area can be treated with Botox injections.


Botox, otherwise known as botulinum toxin, is a toxin that is used extensively for treating wrinkles on the face. Botox works as a muscle relaxant, but it also has been found to reduce sweating. Botox is injected with a needle into the skin, so there is some pain involved in this method of treating excessive sweating.


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JUNE 2006: Sweating associated with diseases no-sweat-line

Medical Publication:

Hyperhidrosis in Parkinson's disease.

Moving Disorders, 2006. no-sweat-line


Synopsis: 50 patients with Parkinson's disease were studied. 13 of them complained of excessive sweating, the other 37 had no sweating problems.


A scientific device measured the skin's sweating response to electrical stimulation of the palms. It was determined that the patients who originally complained of excessive sweating had decreased sweating in response to electrical stimulation than those who never complained of excessive sweating. The authors, although somewhat puzzled by the results, theorized that increased underarm sweating could be a compensatory phenomenon for reduced sweating in the palms.


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Medical Publication:

Hyperhidrosis: a new and often early symptom in Fabry disease.

International Journal of Clinical Practice. 60(9): 1053-9, 2006. no-sweat-line


Synopsis: Fabry disease is an inherited disorder that affects the heart, kidneys and nerves, which oftentimes leads to an increase in sweating and even hyperhidrosis.


Fabry disease results from an enzyme deficiency that leads to the deposit of fatty substances in the blood vessels. One of the hallmark symptoms of Fabry disease is hypohidrosis, that is a increase in sweating. These authors described the unusual cases of Fabry disease patients with hyperhidrosis, i.e. excessive sweating.


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